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In the context of AD and other neurodegenerative disorders, silk nanoparticles enable versatile therapeutic delivery, including drugs and other active agents targeting specific cell types (Mathur and Gupta, 2010) and have demonstrated the ability to bypass the BBB and reach deep brain regions (Yonesi et al., 2021)

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ROS generation can also trigger autocatalytic reactions resulting in more free radicals that propagate the damage chain

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